In Doom there was the BFG-9000, in Gears of War there's the Hammer of Dawn, in Saints Row IV there is the coolest weapon ever named the Dubstep Gun.
The Dubstep Gun is a featured weapon found in the 4th Saints Row game, it's a modified-looking assault rifle with a subwoofer speaker, amplifier, equalizer, and a turntable attached. When fired, it bursts out a pulsating beam of light and dubstep audio onto its target, sending them into a groove state of uncontrollable dance movement until they burst. Not only that, the gun plays one of the best dubstep soundtracks throughout the firing. This gun can be improved to have a wider target range and heavier damage.